![]() ![]() We further investigated the association between mechanical power and days being alive and ventilator free and effect modification of this by a diagnosis of COVID-19. As co-primary analysis, we investigated whether a diagnosis of COVID-19 modified the primary association. The primary outcome was 30-day mortality. The primary exposure was median mechanical power during the first 24 h of mechanical ventilation, calculated using a previously validated formula. This retrospective study included critically ill, adult patients who were mechanically ventilated for at least 24 h between March 2020 and December 2021 at a tertiary healthcare facility in Boston, Massachusetts. We investigated whether an association between higher mechanical power and mortality is modified by a diagnosis of COVID-19. By contrast, mechanically ventilated patients with a diagnosis of COVID-19 may present with intact pulmonary mechanics while undergoing mechanical ventilation for longer periods of time. Previous studies linked a high intensity of ventilation, measured as mechanical power, to mortality in patients suffering from “classic” ARDS.
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